Polyphenols and Their Food Sources

Plant-Based Chemicals With Many Potential Health Benefits

Polyphenols are a group of over 500 phytochemicals, which are naturally occurring micronutrients in plants. These compounds give a plant its color and can help to protect it from various dangers. When you eat plants with polyphenols, you reap the health benefits as well.

You may have heard of phytochemicals, including a number of the polyphenols, without knowing it. They are often the subject of news reports that cover research studies. The claims can include anything from red wine, coffee, and tea to fruits and vegetables that help lower cholesterol or blood pressure, decrease the risks of diabetes or cancer, or lead to a longer life.

Polyphenols are a complicated group of plant-based chemicals. They're found in everyday food and available as supplements. Before you go overboard on seeking them out, however, it's a good idea to understand them.

Foods rich in polyphenols
Verywell / Joshua Seong

Health Benefits

Isolated compounds are often extracted from plants and examined for their potential health benefits. When it comes to research, they sometimes—but not always—have impressive results in the lab.

Foods rich in polyphenols certainly are good for you. However, it's difficult to know how much of that benefit is actually due to the specific plant compound or to all the nutrients, fiber, and other phytochemicals also found in those foods.

The polyphenols typically act as antioxidants. They can help prevent cellular damage from free-radicals that occur with pollution, smoking, eating rancid foods, and as a byproduct of normal metabolism. It's also thought that polyphenols contribute to the body being in an anti-inflammatory state. This is also associated with a lower risk of several chronic diseases.

Several polyphenols, such as quercetin, catechins, lignans, resveratrol, and curcumin, are touted as being anti-cancer agents. Researchers are continuing to study their effect on cancer cells so it's not known if they could prevent cancer or have any effect on cancer cells in a human body.

Polyphenols also appear to improve the function of blood vessels and may help to slow down the formation of blood clots. For example, researchers have found that the catechins in tea may have the ability to slow down the process that causes clogging of the arteries.


8 Things to Know About Polyphenols

Types of Polyphenols

Thinking in terms of chemistry, the polyphenols all have similar ring-shaped structures. You can tell them apart by the number of rings and the other molecules attached to those rings. Thus, polyphenols are grouped into four different categories based on those differences: phenolic acids, flavonoids, stilbenes, and lignans. Within these classes are subclasses.

Phenolic acids include compounds found in coffee, tea, grapes, red wine, berries, kiwi fruits, plums, apples, and cherries. They are found in other fruits and veggies as well, and even grain and corn.

Phenolic acids are abundant in the diet and readily absorbed through the walls of your intestinal tract. You shouldn’t have much trouble consuming enough of them. In general, phenolic acids work as antioxidants but they also appear to promote anti-inflammatory conditions in the body.

Flavonoids are a group of polyphenols that work as both antioxidants and anti-inflammatory agents. They are divided into several groups: flavones, flavonols, flavanones, isoflavones, anthocyanidins, chalcones, and catechins.

Flavonoids are found in a wide variety of plant-based foods, including fruits, vegetables, legumes, red wine, and green tea. Flavonoids—sometimes called "bioflavonoids"—are often sold as dietary supplements.

Stilbenes are a small group of plant chemicals and resveratrol is probably the best-known and the most studied of them. Resveratrol is found in red wine, blueberries, cranberries, and peanuts. Consuming these foods has been linked to better heart health.

It’s hard to know how much of that benefit comes from the resveratrol. Although laboratory studies show that it works as both an antioxidant and anti-inflammatory agent in some laboratory animals, there is very little research that shows that it has any real effects on human health.

Lignans are found in legumes, cereals, grains, fruits, algae, and some vegetables. The best sources include flax and sesame seeds.

Eating a diet rich in lignans may be good for cardiovascular health, but research studies on humans are generally of low quality. Also, it’s not easy to eat a lot of lignans unless you take them as dietary supplements or gulp down spoonfuls of flax seeds.

Polyphenol Supplements

Some polyphenols, such as epigallocatechin gallate (EGCG) and resveratrol, are sold as dietary supplements, usually marketed as antioxidants.

Current research suggests that you'll get the most benefit if you get your polyphenols from foods rather than supplements.

To ensure you eat plenty of polyphenols, you might try:

  • Start with a breakfast featuring whole-grain cereal and coffee. 
  • Snack on fresh fruits rather than candy or cookies.
  • Eat a salad or vegetable soup with dinner.
  • Load your dinner plate with veggies and cut back on the heavy meat and cheese.
  • Enjoy berries as a bedtime snack if you're hungry.

A Word From Verywell

The evidence is stacking up that polyphenols are beneficial to your health, though there are still many questions to be answered. It is clear, however, that eating foods high in these plant chemicals is good for you. Choose a balanced diet with lots of colorful fruits, fresh vegetables, whole grains, and legumes and you'll get plenty of polyphenols.

7 Sources
Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Williamson G. The role of polyphenols in modern nutrition. Nutrition Bulletin. 2017;42(3):226-235. doi:10.1111/nbu.12278

  2. Khurana S, Venkataraman K, Hollingsworth A, Piche M, Tai TC. Polyphenols: Benefits to the Cardiovascular System in Health and in Aging. Nutrients. 2013;5(10):3779-827. doi:10.3390/nu5103779

  3. Soldati L, Di Renzo L, Jirillo E, Ascierto PA, Marincola FM, De Lorenzo A. The influence of diet on anti-cancer immune responsiveness. Journal of Translational Medicine. 2018;16(1):75. doi:10.1186/s12967-018-1448-0

  4. Singhal K, Raj N, Gupta K, Singh S. Probable benefits of green tea with genetic implications. J Oral Maxillofac Pathol. 2017;21(1):107-114. doi:10.4103/0973-029X.203758

  5. Kumar N, Goel N. Phenolic acids: Natural versatile molecules with promising therapeutic applicationsBiotechnol Rep (Amst). 2019;24:e00370. Published 2019 Aug 20. doi:10.1016/j.btre.2019.e00370

  6. Novelle MG, Wahl D, Diéguez C, Bernier M, de Cabo R. Resveratrol supplementation: Where are we now and where should we go?. Ageing Res Rev. 2015;21:1-15. doi:10.1016/j.arr.2015.01.002

  7. Rodríguez-García C, Sánchez-Quesada C, Toledo E, Delgado-Rodríguez M, Gaforio JJ. Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?. Molecules. 2019;24(5). doi:10.3390/molecules24050917

By Shereen Lehman, MS
Shereen Lehman, MS, is a former writer for Verywell Fit and Reuters Health. She's a healthcare journalist who writes about healthy eating and offers evidence-based advice for regular people.