Health Benefits of Forskolin

Plant extract may help treat obesity, glaucoma, and asthma

Flickr Creative Commons https://www.flickr.com/photos/shanfari/6147642027/in/photolist-anfgN4-mgEJVs-8wo72d-ani977-ani5QE-i29qg2-kjyNC8-cAt62b-YGsTa1-3cpHKv-pEeMcV-av5ALZ-gFY8ZM-92B4z5-TgwFCp-6ojgNy-de9hse-hKGs6B-a7XZUb-azBxCz-d6oKrS-atkJQm-8Y4wJ2-ani8ej-8wo553-sEEe4X-cgeZnu-wonaeX-232BRrU-a7XZYy-a7VKqG-cMNWaC-aAV6X2-a7VKws-d3HnFY-jr6Nfg-a7V8eB-51D7s5-d3Hmyu-esXGVG-d8N1Ns-945ff9-rrri8D-qsWp3a-rpXMRc-eqd5CW-d3Hs6d-x5Kxcc-ow332Q-xgvJWm
Indian coleus (Coleus forskohlii).

 Muhammed Al Shanfari

 

In This Article

Forskolin is a natural substance extracted from the root of the Indian coleus plant (Coleus forskohlii), a herb related to mint. The plant is native to India, Nepal, and parts of Southeast Asia and has been used for centuries in Ayurvedic and folk medicines.

Forskolin is known to activate adenylate cyclase class III (AC-III), an enzyme involved in the regulation of all human cells. The primary function of AC-III is to facilitate the transfer of chemical messages from the outside of the cell to the inside of a cell.

By stimulating AC-III, forskolin is believed to promote weight loss, increase lean muscle and bone mass, and treat diseases like glaucoma and asthma.

Health Benefits

Alternative practitioners have attributed forskolin with a multitude of medicinal properties, including the treatment or prevention of heart disease, angina, irritable bowel syndrome, urinary tract infections, eczema, psoriasis, thyroid disease, and high blood pressure.

While many of these claims remain unproven, recent studies suggest that forskolin may, in fact, offer certain health benefits.

Weight Loss

Forskolin may help treat obesity, according to a small study published in Obesity Research. For this investigation, 30 overweight or obese men were assigned either a forskolin supplement (250 milligrams twice daily) or a placebo.

At the end of the 12-week study, men who took forskolin achieved greater losses in body fat and increases in lean muscle mass compared to the placebo group. They also experienced significant increases in bone mass and testosterone.

Despite the positive findings, the results have not been replicated in other studies. Further research would be needed to establish whether forskolin is the weight-loss remedy many people believe it to be.

Glaucoma

Early research suggests that eye drops containing forskolin may help protect against glaucoma, a group of diseases characterized by abnormally high inner eye pressure.

A 2013 study from Italy reported that a supplement containing forskolin and the flavonoid called rutin reduced inner eye pressure by 10 percent in people with glaucoma after 30 days. Higher doses corresponded to greater decreases in eye pressure.

A similar study from India reported that a 1% forskolin eye drop was able to reduce inner eye pressure in 90 adults with moderately severe glaucoma after four weeks of treatment.

Asthma

Forskolin may help fend off asthma attacks, says a 2006 study from the Journal of International Medical Research. The six-month investigation, which involved 40 adults and children with persistent asthma, concluded that forskolin supplements reduced the incidence of attacks better than sodium cromoglycate, a common asthma medication.

A similar study from Mexico reported that a 10-milligram daily dose of forskolin compared favorably to twice-daily inhalations of the asthma drug Qvar (beclomethasone) in reducing the number of asthma attacks.

Where forskolin underperformed was in its ability to improved respiratory function (as measured by the FEV1) . By comparison, Qvar improved all respiratory values, meaning that overall breathing capacity was increased with routine use.

Forskolin works in a similar way to many asthma drugs by boosting the level of a compound known as cyclic adenosine monophosphate (cyclic AMP). Doing so relaxes the air passages and reduces the risk of respiratory spasms.

Possible Side Effects

Forskolin supplements do not appear to be harmful, although their long-term safety has yet to be established. Some people may experience side effects after taking forskolin, including headaches, lightheadedness, flushing, blurry vision, clammy skin, and nausea. Many of these symptoms are related to a sudden drop in blood pressure (known as hypotension).

Forskolin is known to interact with certain chronic medications. Avoid forskolin if you are taking any of the following:

Forskolin should also be avoided in people with polycystic kidney disease (PKD). The drug appears to accelerate the growth of kidney cells and may end up creating additional cysts.

Due to the lack of safety research, forskolin should not be used in children, pregnant women, and nursing mothers.

Dosage and Preparation

There are no guidelines directing the appropriate use of forskolin supplements. The supplements are most commonly sold in capsule form but are also available as tinctures, extracts, and soft gels. They are easily sourced online and can also be found in natural food stores, supplements stores, and some retail pharmacies.

Forskolin supplements are typically manufactured in doses ranging from 385 milligrams to 500 milligrams. As a general rule of thumb, never exceed the recommended dose on the product label.

What to Look For

Dietary supplements are not strictly regulated in the United States and can vary considerably from one brand to the next. To ensure quality and safety, only choose supplements that have been tested and certified by an independent certifying body like the U.S. Pharmacopeia (USP) or ConsumerLab.

Forskolin is often included in weight loss supplements marketed as "fat burners" or "appetite suppressant." Other manufacturers will infer that forskolin can aid in the treatment of thyroid disease or reduce cardiovascular risk. As convincing as a pitch may be, don't be swayed by health claims that may or may not be true.

Other Questions

Can you get forskolin from coleus plants?

While forskolin is derived from the Indian coleus plant, there is no evidence that consuming the coleus offers any health benefits. Coleus plants are not toxic per se but are not really edible either. Moreover, the sap in the plant can sometimes cause skin, mouth, or throat irritation if touched or eaten.

Was this page helpful?

Article Sources

  1. Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and futureJ Tradit Complement Med. 2016;7(2):234–244. Published 2016 Jun 28. doi:10.1016/j.jtcme.2016.05.006

  2. Alberts B. The Structure and Function of DNA. Molecular Biology of the Cell. 4th edition. Published 2002.

  3. Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005;13(8):1335-43. doi: 10.1038/oby.2005.162

  4. Jonas JB, Wang N. Cerebrospinal fluid pressure and glaucoma. J Ophthalmic Vis Res. 2013;8(3):257–263..4103/0301-4738.73695. PMID: 24349669

  5. González-sánchez R, Trujillo X, Trujillo-hernández B, Vásquez C, Huerta M, Elizalde A. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial. J Int Med Res. 2006;34(2):200-7. doi: 10.1177/147323000603400210

  6. Katz S, Arish N, Rokach A, Zaltzman Y, Marcus EL. The effect of body position on pulmonary function: a systematic reviewBMC Pulm Med. 2018;18(1):159. Published 2018 Oct 11. doi:10.1186/s12890-018-0723-4

  7. Thiermann H, Szinicz L, Eyer P, Felgenhauer N, Zilker T, Worek F. Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning. Toxicology. 2007;233(1-3):145-54.

  8. Putnam WC, Swenson SM, Reif GA, Wallace DP, Helmkamp GM, Grantham JJ. Identification of a forskolin-like molecule in human renal cysts. J Am Soc Nephrol. 2007;18(3):934-43. doi: 10.1681/ASN.2006111218

  9. Dwyer JT, Coates PM, Smith MJ. Dietary Supplements: Regulatory Challenges and Research ResourcesNutrients. 2018;10(1):41. Published 2018 Jan 4. doi:10.3390/nu10010041

  10. Henderson S, Magu B, Rasmussen C, et al. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr. 2005;2(2):54–62. Published 2005 Dec 9. doi:10.1186/1550-2783-2-2-54

Additional Reading