Supplements Supplements Guide Supplements Guide Overview Benefits and Risks Regulation Who May Benefit Purchasing Tips Which To Take What To Skip What To Buy 8 Reasons You May Need a Dietary Supplement, According to an Expert By Rebecca Jaspan, MPH, RD, CDN, CDCES Rebecca Jaspan, MPH, RD, CDN, CDCES Rebecca Jaspan is a registered dietitian specializing in anorexia, binge eating disorder, and bulimia, as well as disordered eating and orthorexia. Learn about our editorial process Published on December 08, 2022 Medically reviewed Verywell Fit articles are reviewed by board-certified physicians and nutrition and exercise healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Barbie Cervoni MS, RD, CDCES, CDN Medically reviewed by Barbie Cervoni MS, RD, CDCES, CDN Facebook LinkedIn Twitter Barbie Cervoni MS, RD, CDCES, CDN, is a registered dietitian and certified diabetes care and education specialist. Learn about our Medical Review Board Print Tanja Ivanova / Getty Images Table of Contents View All Table of Contents You Have an Identified Deficiency You Are at Risk for a Specific Deficiency You Follow a Vegan Diet You Don't Get Enough Protein Your Goal Is to Gain Muscle You're Pregnant (or Looking to Become Pregnant) You Want to Boost Your Immunity You're an Older Adult Frequently Asked Questions Next in Supplements Guide 6 Things to Look for When Buying Dietary Supplements It seems as if everyone is taking one supplement or another. In fact, dietary supplements are a more then $60 billion industry in the United States. Regardless of whether you want to get stronger, boost your immunity, or correct a deficiency, a supplement may be right for you. While nothing replaces nutrients coming directly from food, supplements may play a necessary role in your diet. But choosing a dietary supplement can be tricky, which is why its important to turn to healthcare experts for evidenced-based recommendations. Supplements range anywhere from vitamins and minerals to omega-3 fatty acids and branch chain amino acids. And while they may not always be medically indicated, there are some instances where they may be helpful. Here are some potential reasons you may need a dietary supplement. You Have an Identified Deficiency If you are concerned about a nutrient deficiency, it is always a good idea to have bloodwork done to obtain the data first. Then, if you have evidence of a deficiency, talk with a healthcare provider about supplements you may need to correct it. The most common deficiencies in the U.S. are vitamin B6, iron, and vitamin D. If your bloodwork indicates a deficiency in any of these nutrients, a supplement may be warranted. Vitamin B6 is a water-soluble vitamin is that is naturally present in many foods. It is responsible for a number of important functions in the body, including protein, carbohydrate, and fat metabolism. Vitamin B6 also plays a role in cognitive development, immune function, and hemoglobin formation. Why Aren't Dietary Supplements Regulated? Vitamin B6 A deficiency in vitamin B6 is associated with microcytic anemia, cognitive abnormalities, dermatitis with cheilosis (cracks at the corners of the mouth), glossitis, depression, confusion, and weakened immune function. B6 deficiency can also result from diseases that cause malabsorption, such as celiac disease, Crohn's disease, or ulcerative colitis. Vitamin B6 is commonly found in multivitamins or as a stand-alone supplement. Taking a supplement if recommended by your healthcare provider can help alleviate symptoms of deficiency. Iron Another common deficiency, particularly in women, is iron. Its primary role is to support erythropoiesis, or the formation of red blood cells. Every cell and organ system requires iron for proper development and metabolic function. Iron-deficiency anemia occurs when you do not have enough iron in your blood, and therefore, a decreased level of hemoglobin in your red blood cells, causing a deficiency in the oxygen delivered to your tissues. Common causes of iron-deficiency include loss of blood to heavy menstruation or pregnancy, a poor diet, or intestinal diseases that affect how iron is absorbed. Symptoms of iron deficiency include fatigue, weakness, pale skin, shortness of breath, dizziness, and cold hands and feet. Taking iron supplements can help restore iron levels in your body and solve issues related to anemia. Vitamin D The best source of vitamin D is from sunlight and because many parts of the country do not get adequate sunlight all year round, vitamin D deficiency is common. Vitamin D is important for immune health and it is critical to bone health. It also may help protect against cancer, depression, type 2 diabetes, heart disease, and multiple sclerosis. Symptoms of vitamin D deficiency include frequent illness or infections, fatigue, bone and back pain, depression, impaired wound healing, bone loss, and muscle pain. Oral supplements are a go-to treatment for vitamin D deficiency. Ask a healthcare provider for the recommended dosage based on your unique situation. The Best Vitamin D Supplements of 2023, According to a Dietitian You Are at Risk for a Specific Deficiency Certain conditions may put you at risk for a specific deficiency. If this is the case, your healthcare provider will likely have you obtain regular bloodwork to monitor your nutritional status. For instance, if you have a gastrointestinal disorder such as celiac disease, Crohn's disease, or ulcerative colitis, you have an increased risk of calcium, magnesium, zinc, iron, vitamin B12, folate, and vitamin D deficiencies. Additionally, if you have gastric surgery such as a bowel resection or bariatric surgery, you are at risk for the same deficiencies and supplements are likely needed. A number of prescription medications may cause depletion of certain nutrients as well. For instance, some cancer drugs cause folate deficiencies. Meanwhile, angiotension-converting enzyme inhibitors—a blood pressure medication—competes with binding sites for zinc. About 6% to 30% of individuals who take metformin for diabetes management show vitamin B12 deficiencies. The severity of the deficiency depends on the dose and duration of treatment. A B12 supplement may be needed to correct for this deficiency. You Follow a Vegan Diet If you follow any diet that removes certain food groups, you may be at risk for a deficiency. There are a number of nutrients that are either most available or only available in animal products. Vegans are at risk for deficiencies of these nutrients that are not as prevalent in plant-based foods. These nutrients include calcium, iron, zinc, vitamin B12, vitamin D, protein, and omega-3 fatty acids. One study assessed the nutrition status of vegans who took supplements and non-vegans. The study found very little difference between the groups, which was attributed to the high rate of supplementation. How Vitamin B12 Deficiency Affects the Body You Don't Get Enough Protein If you follow a vegetarian or vegan diet or you have a preference for foods lower in protein, you might be at risk of not getting enough protein. Not eating enough protein can result in poor growth, anemia, physical weakness, edema, vascular dysfunction, and impaired immunity. Using protein powder to supplement your protein intake can be a convenient way to increase your protein intake. Add protein powder to smoothies, soups, baked goods, and oatmeal. The 12 Best Vegan Protein Powders of 2023, Tested and Reviewed Your Goal Is to Gain Muscle In addition to strength training and eating enough overall calories, if your goal is to gain muscle, you may need additional protein and supplements. According to the American College of Sports Medicine, to increase muscle mass it is recommended that a person who lifts weights regularly eat between 1.2 to 1.7 grams of protein per kilogram of body weight per day. While it is always good to get your protein through food, protein powder can be added to meals and snacks for an extra boost to make sure you are meeting your needs. Studies show that creatine can also help to increase muscle mass, strength, and exercise performance. On a molecular level, creatine shares similarities with amino acids, the building blocks of protein. Your body produces creatine from the amino acids glycine and arginine. Research shows that taking creatine can alter several cellular processes that lead to increased muscle mass, strength, and recovery. Another important supplement you may need for muscle gain are branched-chain amino acids (BCAAs). They are a group of three essential amino acids, leucine, isoleucine, and valine, that cannot be produced by the body. They must be consumed through food or supplements. While many people eat enough protein foods that contain these amino acids, there is evidence that taking a BCAA supplement can help increase muscle growth and maintenance. The Best Creatine Supplements of 2023 for Strength Training You're Pregnant (or Looking to Become Pregnant) Your body has increased nutritional needs during pregnancy and you may want to get your body ready for pregnancy from a nutritional standpoint as well. For all pregnant people, it is recommended to take a prenatal vitamin. You'll want to look for a prenatal vitamin that includes enough calcium, folate, choline, iron, and omega-3 fatty acids that are essential during pregnancy. Your healthcare provider or prenatal dietitian can advise you on what vitamin or combination of vitamins are best for you based on your individual diet and needs. 17 Healthy Foods, Meals, and Food Alternatives to Eat When You're Pregnant You Want to Boost Your Immunity Good nutrition and getting enough macronutrients and micronutrients are important for a strong immune system. There are many products on the market that may claim to boost your immunity, but be wary of these claims and only use products that are proven. Research has shown that taking supplements of certain vitamins, minerals, and herbs may help improve your immune response and protect against illness. Vitamin D is important for the health of your immune system. Deficiency in vitamin D is associated with increased risk of upper respiratory tract infections. Studies show that supplementing with vitamin D may help improve the immune response. Zinc is also a mineral essential to healthy immune function. Zinc is needed for immune cell development and plays a role in the inflammatory response. Research shows that 16% of deep respiratory infections have been found to be due to zinc deficiency. Perhaps the most commonly taken supplement for the immune system is vitamin C. Vitamin C plays an important role in supporting the function of immune cells and enhances their ability to protect against infection. Research shows that supplementing with vitamin C has been shown to decrease the severity and duration of upper respiratory tract infections. Black elderberry has been used for many years to treat infections and is now being researched for its use as a supplement for immune health. Elderberry extract contains potent antibacterial and antiviral potential against bacterial pathogens. It is also shown to enhance the immune response and shorten the duration of viral infections. The 6 Best Immune Supporting Supplements, According to a Dietitian You're an Older Adult Not only do certain vitamin and mineral needs increase as you age, but reduced appetite may pose a challenge to getting enough nutrition for older adults. While it best to get your nutrients through food, talk with a healthcare provider to determine if a supplement is right for you. As you age, there is a decrease in the efficiency by which the skin absorbs vitamin D. Additionally, older adults may get less sunlight. A vitamin D supplement may needed to protect immune and bone health. Summary Most people can get nutrients they need from a balanced and varied diet. It is also a good idea to take a look at the quality of your diet and see how you can improve it before turning to a supplement.Not everyone needs a dietary supplement and taking more than you need isn't necessarily better. Always test your blood levels for necessity. And, don't guess when making the decision to take a supplement. A Word From Verywell Dietary supplements can certainly serve an important purpose in an individual's diet depending on their needs and nutrition goals. Always consult with a healthcare provider and a registered dietitian before starting a supplement. A registered dietitian can give you specific recommendations for your individual nutrition needs and goals. Seek guidance if you are feeling any physical symptoms and ask for a blood test that indicates a deficiency—especially if you are pregnant, have medical condition that may put you at risk for deficiencies, or you feel you have any nutritional gaps in your diet. Frequently Asked Questions What are a few benefits of dietary supplements? Supplements can provide extra nutrients when your diet is lacking or you have certain health conditions that may put you at risk for a deficiency. Benefits of supplements include maintaining general health, gaining muscle mass and improving bone mass, and providing immune support. Learn More: Benefits and Risks of Taking Dietary Supplements What are the pros and cons of taking dietary supplements? The pros of taking a dietary supplement include ensuring you are receiving all micronutrients your body needs. Supplements also can treat a deficiency, and they can promote muscle gain.The cons of taking supplements include that they are not regulated by the Food and Drug Administration (FDA) and manufacturers do not have to prove that they are safe or effective. It is important to look for third-party tested supplements. Supplements also can be expensive and may not be necessary to take. Keep in mind, too, that taking too much of certain supplements can have adverse side effects. Learn More: When Is the Best Time to Take Supplements? When should I take dietary supplements? You should take a dietary supplement if you have a known deficiency, you are vegan (and are unable to meet your nutrient needs via diet alone), or if you have a medical condition that may put you at risk for a deficiency, such as Crohn's disease or celiac disease. You also want to take a supplement, like a prenatal vitamin, if you are pregnant or looking to become pregnant. Learn More: Best Multivitamins for Women 22 Sources Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Fortune Business Insights. Dietary supplements market size & trends. Centers for Disease Control and Prevention. CDC’s Second Nutrition Report: A comprehensive biochemical assessment of the nutrition status of the U.S. population. Stach K, Stach W, Augoff K. Vitamin B6 in Health and Disease. Nutrients. 2021;13(9):3229. Published 2021 Sep 17. doi:10.3390/nu13093229 Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and minerals for energy, fatigue and cognition: A narrative review of the biochemical and clinical evidence. Nutrients. 2020;12(1):228. Published 2020 Jan 16. doi:10.3390/nu12010228 Weisshof R, Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2015;18(6):576-581. doi:10.1097/MCO.0000000000000226 Georgieff MK, Krebs NF, Cusick SE. The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood. Annu Rev Nutr. 2019 Aug 21;39:121-146. doi: 10.1146/annurev-nutr-082018-124213. Epub 2019 May 15. PMID: 31091416; PMCID: PMC7173188. Pfotenhauer KM, Shubrook JH. Vitamin D deficiency, its role in health and disease, and current supplementation recommendations. J Am Osteopath Assoc. 2017;117(5):301-305. doi:10.7556/jaoa.2017.055 Stroh C, Manger T, Benedix F. Metabolic surgery and nutritional deficiencies. Minerva Chir. 2017;72(5):432-441. doi:10.23736/S0026-4733.17.07408-9 Wendimere Reilly, Jasminka Ilich, Prescription drugs and nutrient depletion: How much is known?, Advances in Nutrition, Volume 8, Issue 1, January 2017, Page 23. doi:10.1093/advances/8.1.23 Kim J, Ahn CW, Fang S, Lee HS, Park JS. Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Medicine (Baltimore). 2019 Nov;98(46):e17918. doi:10.1097/MD.0000000000017918 Weikert C, Trefflich I, Menzel J, et al. Vitamin and mineral status in a vegan diet. Dtsch Arztebl Int. 2020;117(35-36):575-582. doi:10.3238/arztebl.2020.0575 Wu G. Dietary protein intake and human health. Food Funct. 2016;7(3):1251-1265. doi:10.1039/c5fo01530h American College of Sports Medicine. Protein intake for optimal muscle maintenance. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition. 2017;14(1):18. doi:10.1186/s12970-017-0173-z Jackman SR, Witard OC, Philp A, Wallis GA, Baar K, Tipton KD. Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans. Front Physiol. 2017;8:390. Published 2017 Jun 7. doi:10.3389/fphys.2017.00390 Kominiarek MA, Rajan P. Nutrition recommendations in pregnancy and lactation. Med Clin North Am. 2016 Nov;100(6):1199-1215. doi: 10.1016/j.mcna.2016.06.004 Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect on haematopoiesis and immune system and clinical applications. Int J Mol Sci. 2018 Sep 8;19(9):2663. doi:10.3390/ijms19092663 Wessels I, Rolles B, Rink L. The potential impact of zinc supplementation on COVID-19 pathogenesis. Front Immunol. 2020 Jul 10;11:1712. doi:10.3389/fimmu.2020.01712 Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017 Nov 3;9(11):1211. doi:10.3390/nu9111211 Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361-365. doi:10.1016/j.ctim.2018.12.004 Remelli F, Vitali A, Zurlo A, Volpato S. Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients. 2019;11(12):2861. Published 2019 Nov 21. doi:10.3390/nu11122861 Vitale K, Getzin A. Nutrition and supplement update for the endurance athlete: Review and recommendations. Nutrients. 2019;11(6):1289. Published 2019 Jun 7. doi:10.3390/nu11061289 By Rebecca Jaspan, MPH, RD, CDN, CDCES Rebecca Jaspan is a registered dietitian specializing in anorexia, binge eating disorder, and bulimia, as well as disordered eating and orthorexia. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit