Supplements The Health Benefits of Pyruvate Uses, dosing guidelines, and preparations By Malia Frey, M.A., ACE-CHC, CPT Malia Frey, M.A., ACE-CHC, CPT Facebook LinkedIn Twitter Malia Frey is a weight loss expert, certified health coach, weight management specialist, personal trainer, and fitness nutrition specialist. Learn about our editorial process Updated on April 30, 2021 Medically reviewed Verywell Fit articles are reviewed by board-certified physicians and nutrition and exercise healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Jonathan Valdez, RDN, CDCES, CPT Medically reviewed by Jonathan Valdez, RDN, CDCES, CPT Facebook Twitter Jonathan Valdez, RDN, CDCES, CPT is a New York City-based telehealth registered dietitian nutritionist and nutrition communications expert. Learn about our Medical Review Board Print JUAN GARTNER / Getty Images Table of Contents View All Table of Contents Benefits Side Effects Dosage and Preparation Precautions Pyruvate is a substance that is made by the body when it metabolizes sugar (glucose). Your body makes all of the pyruvate that it needs, but you can also consume pyruvate in food such as an apple (450 mg) or beer and red wine (75 mg). Some people also take a pyruvate supplement to gain certain health and body benefits. Health Benefits The most popular purported health benefit of pyruvate is weight loss. Pyruvate supplements for increased fat metabolism are sold online and in vitamin shops. But there is no conclusive evidence to support this benefit. One limited study published in 1999 demonstrated a small effect on body composition when 26 healthy men and women consumed 6 grams of pyruvate for six weeks and participated in a program of mild physical activity for 45 to 60 minutes three times per week. However, in 2014 a more robust literature review was conducted involving 6 clinical trials. Study authors concluded that there is not enough evidence to support the use of pyruvate supplements for weight loss. The authors also note that there is not enough information about the safety of the supplements. According to the National Institutes of Health, even though pyruvate supplements claim to help boost fat and calorie metabolism, all of the studies were too weak to support these benefits. Some people also use pyruvate for cosmetic purposes. Applied to the skin or as a facial peel, some believe that it can relieve dryness or reduce wrinkles and other signs of aging. One small study involving 20 female patients demonstrated that four sessions of 50% pyruvic acid peels in four-week intervals may be modestly effective for managing aging skin. Lastly, authors of a study performed on mice concluded that pyruvate supplementation may counteract aging-related behavioral impairment, but did not provide direct memory enhancement. Further studies are needed to investigate this potential benefit in humans. The Skinny on Fat Burners for Weight Loss Possible Side Effects Pyruvate is possibly safe when taken by mouth in supplement form. However, side effects may include diarrhea, gas, bloating, and (possibly) decreased HDL levels, according to the NIH. However, health experts caution that women who are pregnant or breastfeeding or those who have irritable bowel syndrome may want to avoid pyruvate. Also if you have diarrhea, pyruvate may make it worse. Dosage and Preparation Pyruvate supplements are available in different amounts primarily in capsule form. Doses in amounts of 5 to 44 grams daily have been used in combination with diet and exercise for weight loss. No specific guideline for pyruvate dosing is provided. According to the National Institutes of Health, few safety concerns have been reported for up to 30 grams per day for as long as six weeks. They note however that appropriate doses have not been but not well studied. What is a Supplement? What to Look For When buying any dietary supplement, it is important to read ingredient information carefully before making a purchase. It especially important that a reputable third-party seal is on the packaging because the FDA doesn't regulate the safety or effectiveness of supplements. Look for seals from third-party organizations such as USP, NSF, and Consumer Labs. These organizations ascertain the product is free from impurities and toxins while confirming the ingredient list is accurate. A supplement product may contain more than just the ingredient that you are looking for. And even if a label says that it is "natural," that doesn't necessarily mean that it is safe. Since dietary supplements can interfere with other medication and certain medical conditions, it's important to talk to your healthcare provider before choosing to take one. The National Institutes of Health provides a tip sheet for consumers who are interested in taking dietary supplements. Sources Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Pyruvate. Professional Monograph. Natural Medicines Comprehensive Database. 11/5/2017. Dietary Supplements for Weight Loss. Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements. Gheresitich I, Brazzini B, Perris K, et al. Pyruvic acid peels for the treatment of photoaging. Dermatol Surg 2004;30:32-6. DOI: 10.1111/j.1524-4725.2004.30002.x. Gray, L. R., Tompkins, S. C., & Taylor, E. B. (2013). Regulation of pyruvate metabolism and human disease. Cellular and molecular life sciences : CMLS, 71(14), 2577-604. DOI: 10.1007/s00018-013-1539-2. Kalman, D., Colker, C. M., Wilets, I., Roufs, J. B., & Antonio, J. (1999). The effects of pyruvate supplementation on body composition in overweight individuals. Nutrition, 15(5), 337–340. DOI: 10.1016/s0899-9007(99)00034-9. Koivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Barrera, G. A., Stridh, M. H., Waagepetersen, H. S., Tiainen, M., Soininen, P., Zilberter, Y., … Tanila, H. (2016). Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice. Frontiers in aging neuroscience, 8, 41. DOI: 10.3389/fnagi.2016.00041. Onakpoya, I., Hunt, K., Wider, B., & Ernst, E. (2013). Pyruvate Supplementation for Weight Loss: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Critical Reviews in Food Science and Nutrition, 54(1), 17–23. DOI: 10.1080/10408398.2011.565890. Stanko, R. T., Reynolds, H. R., Lonchar, K. D., and Arch, J. E. Plasma lipid concentrations in hyperlipidemic patients consuming a high-fat diet supplemented with pyruvate for 6 wk. Am J Clin Nutr 1992;56(5):950-954. DOI: 10.1093/ajcn/56.5.950. By Malia Frey, M.A., ACE-CHC, CPT Malia Frey is a weight loss expert, certified health coach, weight management specialist, personal trainer, and fitness nutrition specialist. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit