Instant Knockout: Benefits, Side Effects, Dosage, and Interactions

Instant Knockout is marketing as an energy-promoting diet supplement.

Instant Knockout


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In the popular and ever-growing diet supplements market, manufacturers of Instant Knockout advertise their product as a metabolism booster that leads to less fat storage. Originally developed for professional mixed martial artists and boxers, Instant Knockout now markets itself to all types of athletes of both genders.

Made with extracts of green tea extract for fat burning, cayenne pepper seeds for boosting insulin sensitivity, glucomannan to make you feel fuller faster, caffeine anhydrous to stimulate your nervous system and Vitamin B6 to promote energy, Instant Knockout manufacturers tout its carefully chosen, all-natural ingredients and guarantee results of a fighting-fit physique.

Health Benefits

According to the Centers for Disease Control and Prevention (CDC), all states have an obesity level higher than 20% of adults. The prevalence of this ever-expanding epidemic affects almost 100 million adults, and obesity-related conditions such as heart disease, type 2 diabetes and cancer remain the top causes of preventable deaths. As these numbers continue to rise, people look to supplements to combat weight gain.

One such diet supplement, Instant Knockout, promotes its fat-burning blend of ingredients that can provide peer-reviewed health benefits, such as the following: 

Weight Loss

The green tea extract found in Instant Knockout can indeed promote weight loss, according to a meta-analysis published in the International Journal of Obesity. Researchers reviewed 11 articles that provided information about weight loss and weight management after green tea supplementation. They found that green tea significantly decreased both body weight and body weight management after weight loss.

Boosts Insulin Sensitivity

Consuming cayenne pepper seeds can boost insulin sensitivity, per a study published in the American Journal of Clinical Nutrition. Researchers investigated the metabolic effects of eating a chili-containing meal versus a bland one in 36 participants. They found that chili can have significant results on insulin, leading to increased energy levels and decreased fat.

Lower Cholesterol

In a systemic review and meta-analysis published in the American Journal of Clinical Nutrition, glucomannan was found to beneficially affect total and LDL (otherwise known as "bad") cholesterol levels within 14 different studies.

Possible Side Effects

You can experience side effects when taking Instant Knockout. This blend of ingredients is designed with a high amount of caffeine from the green tea and can disrupt your normal schedule when you first incorporate the product into your diet. Thus, you might incur the following side effects:

  • Difficulty falling asleep. This could happen because of Instant Knockout's natural stimulants. You might want to start taking only two capsules before lunchtime to lessen your caffeine intake later in the day.
  • Choking. You should take each of the four capsules with a large glass of water to help the pill go down.
  • Upset stomach. If you feel nauseated or vomit, you should lessen your intake. Try halving the dosage for a while before going back up to four pills a day, per the recommended dosage. Although manufacturers advise taking the pill before meals, you might find eating it with food is helpful on a meek stomach.
  • Headaches. With the stimulants, especially if you do not normally ingest caffeine, you could get headaches. You can also help with this issue by reducing the amount of pills you take per day and slowly building up to the four times/day dosage.

Dosage and Preparation

According to the product, to receive the full effect of Instant Knockout, you should consume one red capsule four times per day at the following times:

  • When you get up in the morning
  • Before you eat lunch
  • In the afternoon
  • Before you eat dinner

You should take them all before dinnertime.

What to Look For

Instant Knockout is not sold in big box stores. You need to purchase the product from its manufacturers or authorized dealers. If you don't, then you most likely purchased a knockoff.

In addition, the label shouldn't say this product can treat or cure a disease. If it does say so, you have purchased a knockoff.

Other Questions

Is anything in Instant Knockout misleading?
Instant Knockout contains glucomannan, which does offer proven benefits. Glucomannan is often recommended for weight loss throughout the health and fitness industry. But in a systemic review and meta-analysis published in the Journal of the American College of Nutrition, researchers found that evidence from nine studies didn't support that consuming glucomannan results in any significant weight loss.

Also, taking Instant Knockout will most likely not result in a new, miraculous body shape. To properly lose weight, you should eat a healthy diet, follow an exercise regime and not smoke.

Instant Knockout looks like it's marketing toward athletes. Can anyone take the supplement?
Instant Knockout has changed its marketing to become more inclusive of women and people of all exercise backgrounds. However, whether you are an accomplished athlete or simply want to lose weight, you should consult a medical professional before taking supplements to determine if Instant Knockout would serve you well in meeting your health and fitness goals.

Does Instant Knockout contain any banned substances?
Instant Knockout is not known to contain any banned substances. Bodybuilders and athletes can take it and should pass any drug test.

6 Sources
Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. Adult Obesity Prevalence Maps.

  2. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysisInt J Obes (Lond). 2009;33(9):956‐961. doi:10.1038/ijo.2009.135

  3. Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Effects of chili consumption on postprandial glucose, insulin, and energy metabolismAm J Clin Nutr. 2006;84(1):63‐69. doi:10.1093/ajcn/84.1.63

  4. Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysisAm J Clin Nutr. 2008;88(4):1167‐1175. doi:10.1093/ajcn/88.4.1167

  5. Tenore GC, Daglia M, Orlando V, et al. Coffee and Depression: A Short Review of Literature. Curr Pharm Des. 2015;21(34):5034‐5040. doi:10.2174/1381612821666150825145112

  6. Onakpoya I, Posadzki P, Ernst E. The Efficacy of Glucomannan Supplementation in Overweight and Obesity: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Am Coll Nutr. 2014;33(1):70‐78. doi:10.1080/07315724.2014.870013

By Jennifer Purdie, M.Ed, CPT
Jennifer Purdie, M.Ed, is a certified personal trainer, freelance writer, and author of "Growth Mindset for Athletes, Coaches and Trainers."