How to Choose the Best Gluten-Free Probiotics for You

Woman with probiotic pill in hand
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If you have digestive issues, it wouldn't be unusual for you to try supplements such as probiotics—advertised to normalize digestion—for help.

And so, it's unsurprising that many people with celiac disease or non-celiac gluten sensitivity look for gluten-free probiotics to augment their possibly dysfunctional digestive systems.

Not all probiotics are gluten-free (although most are) and may contain dairy (an issue if you're also sensitive to the lactose and/or casein found in dairy products).

Tips for Choosing a High-Quality Probiotic

Generally speaking, the best probiotics share several characteristics.

You should look for products that have high numbers of colony-forming units (CFUs)—the higher the better (most of the best ones have numbers in the tens of billions). In addition, check manufacturing and expiration dates. Probiotics begin to lose their potency when they leave the factory.

Some probiotics need to be refrigerated while others are "shelf-stable," something you may want to consider if you travel frequently (and don't want to lug a cooler around just for your probiotics). Some probiotic formulas also contain prebiotics, which are non-digestible oligosaccharides (long chains of carbohydrates) that feed specific groups of probiotics. For instance, galacto-oligosacharrides (GOS), increase bifidobacterium and lactobacilli, which increases the production butyrate acid, a shot chain fatty acid that feeds intestinal cells, keeping them healthy.

Can probioitics improve intestinal damage from celiac disease or assist with gluten digestion? Research that's been done on probiotics in celiac disease has found certain strains can modify the inflammatory immune response. For instance, in one study Bifidobacterium breve BR03 and B. breve B632 reduced an inflammatory response in children with celiac disease (who followed a gluten-free diet). When the treatment stopped, the inflammatory reaction returned.

Another reason individuals with celiac disease may benefit from a gluten-free diet, is that adults with celiac disease were found to have significantly lower levels of the beneficial Bifidobacterium genus than healthy controls. These are known to protect intestinal mucous and reduce inflammatory responses.

And Lactobacillus Rhamnosous GG has shown to restore intestinal barrier integrity following gluten-induced permeability, which benefits individuals with gluten sensitivity as well as during cases of accidental gluten ingestion for those with celiac disease.

Some naturopathic physicians recommend looking for a high-quality probiotic that combines multiple probiotic strains of Lactobacillus and Bifidobacterium.

Which Gluten-Free Probiotics Are Available?

Here's a list of probiotics products that are considered to be gluten-free by their manufacturers. It's not a comprehensive list since there are literally dozens of different probiotics products on the market, but it should provide you with a starting point in your gluten-free probiotics quest.

Available gluten-free probiotics, in alphabetical order:

  • Align: This probiotic, marketed as "24/7 digestive support," contains a strain of Bifidobacterium infantis, which has been studied in people with celiac disease. It's available in four formulations: regular, chewables for kids (cherry smoothie flavor), chewables for adults (strawberry banana flavor), and extra strength (five times the CFU in the other formulations). According to manufacturer Procter & Gamble, Align has been scientifically tested and is gluten-free. The product does contain milk and sodium caseinate (milk protein) and is not guaranteed to be 100 percent soy-free. Align does not require refrigeration and has a 24-month shelf life.
  • CeliAct Gluten-Free Diet Support: While this isn't marketed strictly as a probiotic—it contains a wide variety of vitamins and minerals, and is more of a multivitamin—it also contains 2 billion CFUs of Bacillus Coagulans for digestive support. The product is free of gluten and dairy (although it's made in a facility that also soy, egg, and casein). This supplement should be stored "in a cool, dry place," but does not require refrigeration.
  • Country Life Power-Dophilus: This probiotic by Country Life—a vitamin manufacturer that is certified gluten-free by the Gluten-Free Certification Association—contains a total of 12 billion CFUs of probiotics, with four different strains (including Lactobacillus acidophilus). It's dairy-free in addition to being gluten-free, contains no yeast or soy, and is certified vegan. This product is shelf-stable and does not require refrigeration.
  • Culturelle Digestive Health: This product comes in both capsules and in an orange-flavored chewable form, which would help if you (or a family member) have trouble swallowing pills. It's also available in an extra strength formulation. Regular Culturelle contains 10 Billion CFUs of Lactobacillus GG plus inulin, a prebiotic carbohydrate. Culturelle is gluten-free, dairy-free, and sugar-free, according to the manufacturer. It should be stored in a cool, dry place, but does not require refrigeration.
  • Florastor Probiotics: Florastor probiotics, which come in adult and kids versions, actually contain a form of yeast known as Saccharomyces boulardii lyo. According to the manufacturer, this "friendly" yeast works to displace less friendly microbes from your digestive tract. Florastor products are considered gluten-free and vegetarian. They contain about 33mg of lactose (the same as in a slice of cheese, the manufacturer says), and may contain traces of soy. The product is free of other major allergens. Florastor should not be refrigerated.
  • Kirkman Labs Pro-Bio Gold Hypoallergenic: Kirkman is well-known for making allergen-free formulas, especially for kids on the autism spectrum who are sensitive to a wide variety of foods. This product contains 20 billion CFUs with six different strains of probiotics, including Lactobacillus acidophilus and Bifidobacterium bifidum. It's free of all major allergens, including gluten, corn, egg, soy, and yeast, and is shelf-stable.

A Word from Verywell

Obviously, this is only a small sampling of the probiotics available in your local health food store or online—these products made the list because they're safely gluten-free (and free of other allergens in many cases) and because they have good reputations in the alternative healthcare community.

In taking probiotics, some people stick with one product, while others swear by rotating brands and microbes—the idea there being to build up a diverse population of intestinal microflora. But ultimately, you'll need to decide—in consultation with your doctor—what type and combination of probiotics might work best for your specific health situation.

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  1. Klemenak M, Dolinšek J, Langerholc T, Di gioia D, Mičetić-turk D. Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Dig Dis Sci. 2015;60(11):3386-92. doi: 10.1007/s10620-015-3769-7

  2. Golfetto L, De senna FD, Hermes J, Beserra BT, França Fda S, Martinello F. Lower bifidobacteria counts in adult patients with celiac disease on a gluten-free diet. Arq Gastroenterol. 2014;51(2):139-43. doi:10.1590/S0004-28032014000200013 

  3. Orlando A, Linsalata M, Notarnicola M, Tutino V, Russo F. Lactobacillus GG restoration of the gliadin induced epithelial barrier disruption: the role of cellular polyamines. BMC Microbiol. 2014;14:19. doi:10.1186/1471-2180-14-19

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