What Is the Grapefruit Diet?

Grapefruit diet

Verywell / Debbie Burkhoff 

At Verywell, we believe there is no one-size-fits-all approach to a healthy lifestyle. Successful eating plans need to be individualized and take the whole person into consideration. Prior to starting a new diet plan, consult with your healthcare provider or a registered dietitian, especially if you have an underlying health condition.

The grapefruit diet is a fad diet that has been around since the 1920s and 1930s (possibly earlier). The restrictive eating plan is widely believed to be a byproduct of the Depression Era when it became trendy among actresses, eventually becoming known as "The Hollywood Diet."

The grapefruit diet saw a resurgence in the 1970s, and various iterations of the diet continue to circulate. Over the years, it also became associated (incorrectly) with the Mayo Clinic. In 2004, a book titled "The Grapefruit Solution" suggested that eating grapefruit could improve the success rate of the weight loss plan of your choice.

The focus of any version of the grapefruit diet generally involves eating a few servings of grapefruit a day and tends to be extremely restrictive with other foods. The biggest promise of the grapefruit diet is significant weight loss in a short period of time.

While it's true that grapefruit is a nutritious fruit, it does not necessarily have any magical powers to rev up weight loss.

What Experts Say

"While grapefruits are good for you, the health and fat-burning promises of the grapefruit diet are not evidence-based. The diet's small portions and limited food options are not sustainable, and grapefruit has a high risk of interacting with many medications and conditions."
Kelly Plowe, MS, RD

What Can You Eat?

While many versions of the diet exist, the grapefruit diet's basic premise is consuming grapefruit (typically the whole fruit, though some versions allow for powdered grapefruit supplements) before all three meals a day, for a duration of seven to 10 days or more. Also, there is a restrictive eating plan for those three meals.

While there can be some variation in the grapefruit diet instructions, all call for eating the grapefruit (or drinking grapefruit juice) before meals, most versions consistently call for three meals a day, no snacks, and a fourth meal (or bedtime snack)—usually a glass of skim milk or tomato juice.

What You Need to Know

While nutrition experts don't recommend the grapefruit diet, it can be especially problematic for people who take certain medications as consuming grapefruit (especially frequently or in large amounts) with certain medicines can have adverse health effects.

More than 50 medications are known to interact with grapefruit, but some of the most common medications that are not safe to mix with grapefruit or grapefruit juice include:

  • Thyroid medications: People on thyroid hormone replacement therapy need to avoid consuming too much grapefruit, which can make thyroid medications less effective.
  • Statins: Statin medications—including Lipitor (atorvastatin), Zocor (simvastatin), and Mevacor (lovastatin)—are prescribed to treat high cholesterol, and grapefruit can change the levels of these medications in the blood, as well as increase the likelihood of side effects.
  • Antidepressants: Several medications used to treat depression, bipolar disorder, and other mental health conditions can be affected by certain enzymes in grapefruit.

If you are taking any medications, check with your doctor before adding grapefruit to your diet.

What to Eat
  • Grapefruit

  • Eggs

  • Bacon

  • Chicken or other meat

  • Salad or cooked vegetables

What Not to Eat
  • Other fruits

  • All grains and starches

  • Added sugar

  • Dairy products

  • Beverages other than coffee, tea, or water


As the cornerstone of this diet, the serving size is half a grapefruit or 8 ounces of grapefruit juice. You can also purchase powdered grapefruit in capsule form. For any of these choices, you consume the grapefruit before the rest of the meal.

Eggs and Bacon

Some forms of the grapefruit diet suggest eating two eggs and two strips of bacon every day for breakfast (after the grapefruit).


Lunch and dinner on the grapefruit diet consist of a serving of meat along with a salad. The diet makes no distinction between lean proteins and those with lots of saturated fat. It also doesn't limit portion size.

Salad and Cooked Vegetables

Your choice of meat is paired with a salad or some cooked veggies (some versions specify red or green vegetables only). In most cases, any kind of salad dressing is permitted.

Other Fruits

Some versions of the grapefruit diet allow for other fruit choices, while others do not.

Grains, Starches, and Added Sugars

All grains, starches, and added sugars are excluded from the grapefruit diet, making it very restrictive.


The grapefruit diet encourages water and allows for a cup or two of tea or coffee per day, but no other beverages.

Dairy Products

Some versions of the grapefruit diet allow for one 8-ounce glass of skim milk per day. Other than that, no dairy products are permitted.

Pros and Cons

  • Grapefruit is nutritious

  • Very restrictive

  • Based on false assumptions

Though grapefruit is a nutritious food, a restrictive eating plan that consists of mostly grapefruit eliminates other healthy food groups that are part of a balanced diet.


Beneficial Nutrients

Adding grapefruit to your regular diet can offer some benefits but probably does not directly lead to weight loss. Rather, adding more fruits and vegetables like grapefruit to your diet may aid in weight loss.

Studies have shown that people who consume more fruits and vegetables can eat more volume of food and feel full sooner, and therefore eat fewer calories which may result in weight loss. The fruit is an excellent source of vitamins A and C and the antioxidant lycopene and some flavonoids.

Compared to other fruits, grapefruit is low-calorie and lower in carbohydrates. A full serving of grapefruit (154 grams) has about 2.5 grams of naturally occurring dietary fiber.

Grapefruit is a filling low-calorie, snack. Between the sour taste and the time it takes to peel them, you also can't mindlessly munch your way through several hundred calories' worths of grapefruit the way you might with other snacks.

Grapefruit can have some health benefits, but you should consult with your doctor before including it in your diet.


Very Restrictive

The grapefruit diet is deficient in calories and far too restrictive to be considered healthy for the long term. It excludes almost all carbohydrates and many nutritious foods (such as whole grains and other fruits). Following the diet might also lead to consuming excessive saturated fat since it suggests eating meat twice a day without any recommendation to favor lean proteins.

False Assumptions

One common belief about grapefruit is that it contains a special enzyme that helps burn fat. This is not true. Eating any fruit before a meal could help with weight loss because it reduces your hunger and could curb the total calories you consume. 

Another false argument for the grapefruit diet is that grapefruit is a "negative calorie" food—meaning that you burn more calories chewing and digesting it than it contains. When you burn more calories than you consume, you lose weight. Therefore, the argument is that eating a negative-calorie food would help with weight loss. Grapefruit does contain a relatively small number of calories, but it does not have a "negative calorie" effect.

Half of a regular size grapefruit has around 52 calories. Unless you're doing jumping jacks while you peel, eat, and digest it, it's unlikely that you would burn more calories than it contains.

Is the Grapefruit Diet a Healthy Choice for You?

The grapefruit diet shares many characteristics with other restrictive fad diets that claim to offer quick and easy weight loss, such as the egg diet and the three-day military diet. However, the grapefruit diet contains a kernel of useful advice for people looking to lose weight.

The U.S. Department of Agriculture's (USDA) dietary guidelines suggest consuming a balanced diet of fruits, vegetables, grains, proteins, and dairy products. The USDA recommends consuming roughly 1,600 to 2,400 calories for women and 2,000 to 3,000 calories per day for men for weight maintenance. This calorie level, and the calorie level you require for weight loss, can vary significantly based on age, sex, weight, and level of physical activity. If you're interested in determining your own calorie guidelines, you can use this calculator.

The grapefruit diet typically tops out at less than 1,000 calories per day. That's far fewer than the amount recommended by the USDA, even if you're trying to lose weight. The grapefruit diet also restricts many other healthy foods and is therefore not a recommended eating plan.

Health Benefits

A 2006 study showed that eating grapefruit could lower blood sugar and, for some, lead to weight loss. Participants who ate half a grapefruit before meals for 12 weeks lost significantly more weight than a non-grapefruit-eating control group.

However, a third of the participants showed no change in weight after a six-week dietary intervention (eating half of a fresh grapefruit three times a day). Still, there were some decreases in blood pressure and cholesterol levels in this group.

While proponents of the grapefruit diet claim that it will lead to quick weight loss, research supports that weight loss resulting from similar fad diets is often not sustained and that a grapefruit diet could encourage unhealthy eating habits.

Health Risks

Eliminating healthy foods like all grains could result in deficiencies in B vitamins and trace minerals, more common in those people who follow restrictive diets. Additionally, grapefruit can interfere with many commonly used medications.

Despite the small studies that show some weight loss effects with grapefruit, there is very little high-quality research (large, randomized studies in humans) that supports this claim. Subsisting on mostly grapefruit, protein, and some vegetables is neither a nutritionally balanced nor sustainable weight loss plan.

It's possible to lose weight on the grapefruit diet due to the severe calorie restriction, but a more sustainable option would be to eat a healthy diet that includes grapefruit (if it is safe for you) as part of a sensible weight-loss plan.

A Word From Verywell

While the grapefruit diet commonly found online is not a healthy diet plan, adding more grapefruit to your diet might be—especially if you are trying to lose weight. The fruit is a nutritious, low-calorie choice. If you are taking medications, however, you will need to be aware of how much grapefruit you eat. Some medications that are used to treat thyroid conditions, high cholesterol, and depression can interact with grapefruit and cause adverse side effects.

In general, look for an eating plan that doesn't cut out major food groups, offers the potential for slow and steady weight loss, and addresses your health goals while also being safe. Your doctor or a registered dietitian can help you find a diet that is safe and effective.

Remember, following a long-term or short-term diet may not be necessary for you and many diets out there simply don’t work, especially long-term. While we do not endorse fad diet trends or unsustainable weight loss methods, we present the facts so you can make an informed decision that works best for your nutritional needs, genetic blueprint, budget, and goals.

If your goal is weight loss, remember that losing weight isn’t necessarily the same as being your healthiest self, and there are many other ways to pursue health. Exercise, sleep, and other lifestyle factors also play a major role in your overall health. The best diet is always the one that is balanced and fits your lifestyle.

16 Sources
Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Thomson TL. Ahrens JM. The Grapefruit Solution: Lower Your Cholesterol, Lose Weight and Achieve Optimal Health with Nature's Wonder Fruit. Carlsbad, California: LINX Corporation; 2004.

  2. Bailey DG, Dresser G, Arnold JM. Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?. CMAJ. 2013;185(4):309-16. doi:10.1503/cmaj.120951

  3. Colucci P, Yue CS, Ducharme M, Benvenga S. A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism. Eur Endocrinol. 2013;9(1):40-47. doi:10.17925/EE.2013.09.01.40

  4. Lee JW, Morris JK, Wald NJ. Grapefruit juice and statins. Am J Med. 2016;129(1):26-9. doi:10.1016/j.amjmed.2015.07.036

  5. El-Hage W, Samuel L, Vincent C, Catherine B. Mechanisms of antidepressant resistance. Front Pharmacol. 2013;4:146. doi:10.3389/fphar.2013.00146

  6. Centers for Disease Control and Prevention. Can eating fruits and vegetables help people to manage their weight?.

  7. Murphy MM, Barraj LM, Rampersaud GC. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in women, NHANES 2003-2008. Food Nutr Res. 2014;58. doi:10.3402/fnr.v58.22179

  8. U.S. Department of Agriculture. Grapefruit, raw, pink and red, all areas.

  9. Abdul Hakim BN, Yahya HM, Shahar S, Abdul Manaf Z, Damanhuri H. Effect of sequence of fruit intake in a meal on Satiety. Int J Environ Res Public Health. 2019;16(22). doi:10.3390/ijerph16224464

  10. Buddemeyer KM, Alexander AE, Secor SM. Negative calorie foods: An empirical examination of what is fact or fiction. bioRxiv. doi:10.1101/586958

  11. U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2020–2025 Dietary Guidelines for Americans. 9th Edition.

  12. Fujioka K, Greenway F, Sheard J, Ying Y. The effects of grapefruit on weight and insulin resistance: Relationship to the metabolic syndrome. J Med Food. 2006;9(1):49-54. doi:10.1089/jmf.2006.9.49

  13. Joshi S, Mohan V. Pros & cons of some popular extreme weight-loss dietsIndian J Med Res. 2018;148(5):642-647. doi:10.4103/ijmr.IJMR_1793_18

  14. U.S. Food and Drug Administration. Grapefruit Juice and Some Drugs Don't Mix.

  15. Onakpoya I, O'sullivan J, Heneghan C, Thompson M. The effect of grapefruits (Citrus paradisi) on body weight and cardiovascular risk factors: A systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr. 2017;57(3):602-612. doi:10.1080/10408398.2014.901292

  16. Bertoia ML, Mukamal KJ, Cahill LE, et al. Changes in intake of fruits and vegetables and weight change in United States men and women followed for up to 24 years: Analysis from three prospective cohort studies. PLoS Med. 2015;12(9):e1001878. doi:10.1371/journal.pmed.1001878

By Lisa Lillien
Lisa Lillien is a New York Times bestselling author and the creator of Hungry Girl, where she shares healthy recipes and realistic tips and tricks.