Do Calcium Supplements Interfere with Medications?

Calcium supplements can interfere with some medications.
Paul Bodea

Calcium supplements can interact with several medications in different ways, often increasing or decreasing the amount of the drug that's absorbed. And sometimes it works the other way around — the drug changes how much calcium you absorb.

Supplements are usually safe to take, but you need to consider what else you're taking and what's going with your body. It's important to talk to your healthcare provider about taking calcium or any supplements if you're on any medications, even over-the-counter medications.

Calcium and Antibiotics

Calcium supplements can decrease the absorption of fluoroquinolone and tetracycline. Taking the medications and supplements at least two hours apart should help, but again, speak with your healthcare provider. Calcium supplements should probably be avoided altogether if you're taking gentamicin, another type of antibiotic.

Calcium and Osteoporotic Medications

Bisphosphonates are medications used to treat osteoporosis. Taking them at the same time as calcium supplements may decrease absorption of the medication, so they should be taken at least two hours apart from the calcium. On the other hand, estrogens increase calcium absorption, which can improve bone density

Calcium, Diuretics, and Other Blood Pressure Medications

Diuretics are used to remove fluid from your body and reduce blood pressure. Some types of diuretics may affect your blood levels of calcium. Potassium-sparing and thiazide diuretics can increase the amount of calcium in your blood, and loop diuretics cause calcium levels to go down.

Calcium supplements and beta-blockers may interfere with each other. And, not surprisingly, calcium may interfere with calcium channel blockers. Don't take any calcium supplements with these blood pressure medications unless your healthcare provider tells you to take them.

Calcium, Antacids, and Laxatives

Both aluminum- and magnesium-containing antacids increase the amount of calcium that's excreted in your urine, which means you might lose calcium. And one form of calcium supplements called calcium citrate may increase the amount of aluminum that's absorbed from those antacids.

Some over-the-counter antacids are made of calcium carbonate, which absorbs the acid in your stomach. It's important to follow label instructions to prevent absorbing too much calcium from these antacids.

Laxatives that contain magnesium may decrease the amount of calcium absorbed from calcium supplements.

Calcium and Anti-Seizure Medications

Anti-seizure medications, such as phenytoin, carbamazepine, phenobarbital, and primidone, may lower your calcium levels. They need to be taken at least two hours apart from calcium supplements.

In addition, your healthcare provider may suggest taking vitamin D supplements along with your anti-seizure medications to try to keep calcium levels close to normal levels.

Cholesterol Medications

One type of cholesterol-reducing medication, called bile acid sequestrants, may increase calcium loss in the urine, so your healthcare provider may recommend taking calcium and vitamin D supplements. 

Really, this is so important that it bears repeating: You need to talk to your healthcare provider about any dietary supplements you are taking, especially if you have any health conditions or are taking any medications, including prescriptions and over-the-counter drugs.

2 Sources
Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Institutes of Health; Office of Dietary Supplements. Calcium: Fact Sheet for Health Professionals.

  2. University of Michigan Medicine. Magnesium oxide.

Additional Reading

By Shereen Lehman, MS
Shereen Lehman, MS, is a former writer for Verywell Fit and Reuters Health. She's a healthcare journalist who writes about healthy eating and offers evidence-based advice for regular people.