The 7 Best Probiotics for Men of 2021, According to a Dietitian

Aid digestion by staying aware of potency, strains, and third-party testing

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Our Top Picks
This is designed to support optimal intestinal health and is free of top allergens.
They guarantee that their products are glyphosate residue-free.
It's specially formulated for men's health needs and colon support by including both Lactobacilli and Bifidobacteria.
Designed to be delayed release, it makes sure its contents make it past the acidic environment of the stomach.
Here's a great option for anyone who may be following a gut-healing-specific diet looking for an extra gut-health boost.
Each capsule features specific probiotics strains for digestive, dermatological, and heart health.
One capsule provides ten billion colony forming units of six specific probiotic strains that support immune health.

Probiotics are live microorganisms, considered to be "good bacteria," that support the growth of a healthy gut microbiome. The gastrointestinal tract is host to many of the approximately 100 trillion microorganisms that live in the human body—so it's important to keep it healthy and flourishing.

Probiotic supplement use has soared in recent years due to the continued emerging research on the associated health benefits. Probiotics can be consumed naturally in foods like sauerkraut, yogurt, kombucha, and kimchi, or they can be taken in supplement form. 

Supplemental probiotics can help support the bacteria that live within us, especially when our innate bacteria is challenged, whether by antibiotics, a poor diet, or traveling. 

Probiotics have been shown to help immune function, digestion, and nutrient absorption. The research examining probiotics specifically for men is limited, and more research needs to be done in order to deem which probiotics men will benefit from most. As research continues to emerge in this field, it appears that a broad-spectrum probiotic with a variety of bacterial strains is ideal. Prostate, colon, and heart health may even improve with a probiotic supplement. 

When looking for a probiotic, it is important to make sure that the levels of live probiotics are provided through the ‘best by’ date (not time of manufacture). Though probiotics are safe for most people, consumers should always discuss introducing new supplements with their healthcare provider.

What to Look for in Probiotics for Men

Expiration Date

When looking for a probiotic, it is important that potency is guaranteed through expiration. Avoid labels that read “potency guaranteed at the time of manufacture.” The latter statement means that, though a probiotic may have 30 billion CFUs in the lab, they cannot guarantee that there will still be 30 billion CFUs when the product hits the shelf. 

Strain-Specific Probiotics

When reading a probiotic label, most companies only list the genus and the species. For example: “Lactobacillus (genus) acidophilus (species).” More recently, products are listing the specific strains, for example: “Lactobacillus acidophilus NCFM.” In this instance, NCFM is the strain. Knowing the specific strain is important because you can cross reference them with actual studies that have been done, either on humans or animals, to see if the claims on the bottle were actually examined in research.

Third-Party Certification

Shoppers might see labels such as “CL, Labdoor, NSF, or USP.” These labels indicate that a company has undergone voluntary third-party testing of their products to check for purity, potency, and quality. These third-party companies will also test for heavy metals and other contaminants.

How We Select Supplements

Our team works hard to be transparent about why we recommend certain supplements—you can read more about our dietary supplement methodology here.  

Here are the best probiotics for men:

Klaire Labs Ther-Biotic Complete Probiotic

Klaire Lab’s Ther-biotic Complete Probiotic is an excellent choice for a broad spectrum, multi-function supplement. Designed to support optimal intestinal health, it combines six colonizing Lactobacillus species (normally the predominant microorganisms in the small intestine), four colonizing Bifidobacterium species (healthful organisms found primarily in the colon), and two beneficial lactic acid organisms (commonly used as starter cultures for yogurt).

Anyone who has struggled with allergies knows how tricky it can be to find a supplement that actually helps instead of harms. As a bonus, Klaire Labs grows their probiotics on a dairy-free medium and ensures that their Ther-biotic Complete Probiotic is free of the top eight allergens. If you are curious about production, you can head to their website and take a video tour of their facility. In addition to transparency, Klaire Labs checks their product for potency and guarantees that heat contact from shipping will not disrupt potency.

Innate Response Flora 20-14 Capsules

Innate Response Flora 20-14 Capsules

Looking for a high-quality, multi-species product to nourish your digestive system? Innate Response’s Flora 20-14 probiotic is designed to support intestinal health and immunity with 20 billion live cultures from 14 unique probiotics, including acid-resistant strains. One of the probiotics included in this product is Lactobacillus rhamnosus, which may have a positive effect on weight loss. Research suggests it does this by reducing the body's resistance to the appetite-regulating hormone leptin, helping satiety signals to be "heard" by the body.

Innate Response is one of the first supplement companies to guarantee that their products are glyphosate residue-free, which increases the efficacy of their product by limiting interference from a known microbiome disruptor. Glyphosate, a key ingredient in the weed killer Roundup, has been making headlines recently due to its negative effects on hormones, gastrointestinal health, respiratory health, and immune functioning, among other concerns.

In addition to glyphosate, each batch of incoming ingredients is tested for over 125 different pesticides and herbicides.

Garden of Life Dr. Formulated Probiotics for Men

When taking a probiotic, it is critical to consume prebiotics in order to support the efficacy of the probiotic. Prebiotics are fiber compounds that serve as a nutrient source for probiotics, found in many plant-based foods such as asparagus, onions, Jerusalem artichoke, and garlic. They can also be extracted from foods and added to probiotics for a one-two punch, called a synbiotic.

Garden of Life’s Once Daily Men’s probiotic contains 15 probiotic strains and 50 billion colony-forming units. It also supports the efficacy of the beneficial bacteria through the addition of a prebiotic fiber blend of organic potato and organic acacia fiber. This product is specially formulated for men's health needs and colon support by including both Lactobacilli and Bifidobacteria, which are resistant to stomach acid and bile. 

Great for traveling, this probiotic does not need to be refrigerated. It is also dairy-, gluten-, and soy-free, and vegetarian, making it an excellent choice for those with dietary restrictions.

Renew Life Ultimate Flora Men's Care Probiotic

Renew Life’s Ultimate Flora Men’s Care Probiotic is designed with men’s digestive and colon health in mind. Containing 90 billion colony-forming units of 12 different probiotic strains, this probiotic is intended to restore digestive balance, improve immunity, and promote regularity. It  includes probiotic strains such as Bifidobacterium lactis BI-04 and Lactobacillus acidophilus NCFM, among many others that have been investigated in various research studies and have provided intestinal benefit to study participants.

Ensuring quality and potency through expiration, Renew Life’s capsules are designed to be delayed release, making sure the contents make it past the acidic environment of the stomach. This product is also gluten-, dairy-, and soy-free, and Non-GMO Project Verified.

Lactobacillus rhamnosus GG (LGG) has been used in multiple clinical trials focusing on abdominal pain, infection-induced diarrhea, and allergic reactions such as eczema. Culturelle contains 10 billion colony-forming units of this evidence-backed bacteria strain per serving. To further support the efficacy of this probiotic, it includes 200 milligrams of chicory root extract in each capsule, which serves as a prebiotic.

Independent product testing company, Consumer Labs, confirmed that it contains the listed amount of probiotic organisms and is free of contamination as well as soy, milk, dairy, wheat, gluten, and lactose. This is a great, allergy-friendly option for those looking for an extra gut health boost.

Seed Daily Synbiotic

Seed Daily Synbiotic

If you are wondering what a ‘synbiotic’ is and how it differs from a probiotic, it is a scientific term for a product that contains both a prebiotic and a probiotic in one capsule. Utilizing naturally occurring bacteria strains that have been researched in human-based studies, Seed’s Daily Synbiotic’s benefits extend beyond a sole focus on gut health. Spin the bottle around and you will find a label that breaks down the probiotic strains based on function. 

Each capsule features 53.6 Billion AFU, including specific probiotics strains for digestive, dermatological, and heart health, as well as beneficial bacteria to support micronutrient synthesis. 

To ensure that their pre- and probiotics survive the stomach’s acidity, the potent combination of bacteria strains, specific for dermatological and cardiovascular health (in addition to gut health), are protected in a patented capsule made from microalgae.

The symbiotic does not have to be refrigerated, and the company meticulously tests their products to make sure they are free of gluten, dairy, corn, soy, binders, fillers, and excipients.

Pure Encapsulations Probiotic G.I.

Pure Encapsulations Probiotic G.I.

Pure Encapsulations Probiotic G.I. is a shelf-stable probiotic blend, designed to promote the optimal function of the gut-associated lymphoid tissue, gastrointestinal cell health, and immune response. One capsule provides 10 billion colony-forming units of six specific probiotic strains that have been researched for their role in supporting immune health.

This probiotic blend does not need to be refrigerated, making it a great choice for those on the go. In addition, for those with dietary restrictions, Pure Encapsulations’ products are free from wheat, eggs, tree nuts, peanuts, gluten, artificial colors, flavors, sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers, and preservatives.

Final Verdict

Utilizing naturally occurring bacteria strains that have been researched in human-based studies, Seed’s Daily Synbiotic (view at Seed) extends beyond a sole focus on gut health. Each capsule features specific probiotic strains for digestive, dermatological, and heart health as well as beneficial bacteria to support micronutrient synthesis.

Packaged in a patented capsule that is meant to survive the acidic environment of the stomach, the combination of prebiotics and probiotics work synergistically to support optimal health and well-being. 


How do you know if a probiotic is working? 

Probiotics alone are rarely solely responsible for overwhelming changes in health and well-being, but they can certainly be one important part of feeling well. Keep track of your symptoms when you begin taking a probiotic. If you are taking a probiotic because of digestive issues like gas, bloating, or distressing bowel movements, take note of how you feel daily. It may take a few weeks to see changes. 

If you do not notice any positive changes, you may need to evaluate your diet. Make sure you are consuming enough fiber to support the probiotics. In addition, evaluate other areas of your health such as sleep, hydration, and movement. The combination of both healthy lifestyle changes and a probiotic is necessary to ensure positive outcomes. 

What is the best time to take probiotics?

The best time to take probiotics is whenever you remember to do so. There is conflicting information about what time of day is best to take a probiotic and without definitive scientific evidence, it is hard to make a conclusive statement.

Most probiotics are well tolerated on an empty stomach so, depending on other supplements or medications you are taking, it’s best taken first thing in the morning or at the end of the evening. 

What Experts Say

"Research shows that a healthy gut microbiome is essential for optimal digestion and absorption, improved immune function, and overall GI health. Emerging research on the potential protective effects of a healthy gut against prostate cancer is of particular interest for men. In general, it is best to try and consume probiotics from whole, real foods—think naturally fermented foods or yogurts with live, active cultures. If your diet is low in these foods, supplementing with probiotics may be beneficial. Probiotics feed on prebiotic fibers, so choosing a symbiotic supplement may increase the effectiveness. If you are choosing a probiotic instead, make sure to consume a diet high in prebiotic fiber from fruits, vegetables, and whole grains." — Anne Cook Carroll, MS, RDN

Why Trust Verywell Fit?

As a Registered Dietitian, Sydney Greene takes supplement recommendations seriously. Every product has been researched and vetted by her against clinical research, product reviews, and third-party testing websites. These are products she would not only feel comfortable recommending to her clients but also take herself if needed.

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Article Sources
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