The 9 Best Mushroom Supplements, According to a Dietitian

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Our Top Picks

Best Overall:

Four Sigmatic Mushroom Blend at Amazon

This powder blend of mushrooms is gluten-free, vegan, paleo, and organic.

Best Budget:

NOW Cordyceps at Amazon

These affordable capsules are gluten free, non-GMO and organic.

Best Powder:

SoTru Medicinal Mushrooms Drink Mix at Amazon

This mix includes six of the most powerful mushroom species.

Best Capsule:

New Chapter Reishi Mushroom - LifeShield Immune Support at Amazon

These capsules use technology to verify and guarantee each mushroom strain they use in their supplements.

Best Reishi:

Host Defense Reishi at Amazon

These capsules use a popular, best selling supplemental mushroom that can provide many health benefits.

Best Maitake:

Om Mushroom Superfood Maitake Powder at Amazon

It's certified organic, non-GMO, vegan, and gluten-free.

Best Chaga:

Wellmade Superfood Mushroom Powder Chaga at Thrive Market

This chaga supplement powder is certified organic, non-GMO, ethically sourced, and vegan.

Best Cordyceps:

Moon Juice Cordyceps at Amazon

A powder with a mildly sweet flavor that mixes well with coffee, tea, and plant-based milks, and can even be used in baking.

Best Lion’s Mane:

Pure Essence Lions Mane 4X at Amazon

It is ultra-concentrated, non-GMO, and dairy and gluten free.

In This Article

What to Look For
How We Select Supplements
Our Picks
What Experts Say

Mushroom supplements are a trend that has taken the wellness world by storm. These supplements go beyond your typical grocery store portobello mushrooms and provide a variety of healing benefits. Mushroom supplements are made from types of mushrooms that you may have never heard of—reishi, lion’s mane, and cordyceps, to name a few.

Mushrooms are considered a functional food, meaning they are thought to have health benefits beyond basic nutrition. Functional foods may support optimal health and reduce the risk of certain diseases when taken regularly. Mushroom supplements harness the functional properties of mushrooms in a concentrated form, usually in the form of pills, powders, or drink mixes.

While there is still limited research in humans about the health benefits of mushroom supplementation, there are promising results showing they may help improve blood glucose control, fatigue, and immune response. When choosing a mushroom supplement, it’s important to buy a trusted product because the FDA does not regulate dietary supplements. Some mushrooms are harmful or poisonous to humans, so it’s vital to know you are purchasing supplements made from safe-to-consume ingredients.

What to Look for in Mushroom Supplements

Form

When choosing a mushroom supplement, choose one in a form that you’re most likely to use and enjoy because supplements are most effective when you’re consistent in taking them. A powder supplement may be best if you’re new to supplements or averse to taking them, as you can mix it into a smoothie or your morning coffee. If you’ve already got a solid supplement routine down, try a pill or capsule and add it to your daily supplement regimen. Pills or capsules are also a good choice if you don't like the taste of mushroom supplements.

Quality

Look for mushroom supplements that are third-party tested, whenever possible, to help ensure your supplement contains what it says it does. Select a non-GMO and Organic product to reap the benefits of the highest quality ingredients.

How We Select Supplements

Our team works hard to be transparent about why we recommend certain supplements; you can read more about our dietary supplement methodology here.

Here, the best mushroom supplements:

If you’re just dipping your toes into mushroom supplements, Four Sigmatic's Mushroom Blend powder is an excellent place to start. It harnesses the immune-supporting benefits of ten powerful mushrooms, including reishi, lion’s mane, shiitake, and cordyceps. You’ll get the benefits from all these functional mushrooms in one simple supplement. This powdered supplement is easy to work into your routine because you can stir it into your morning coffee or blend it into a smoothie.

This powder blend of mushrooms is gluten-free, vegan, paleo, and organic. The mushrooms used to make the supplement are farmed naturally or wild harvested.

Dietary supplements can cost a pretty penny, but some brands, like NOW Foods, make much more affordable options. NOW's Cordyceps supplement comes in capsule form for you to take each day.

Cordyceps have been used for centuries in Traditional Chinese Medicine to combat fatigue, anti-aging, inflammation, and illness. These affordable capsules are gluten-free, non-GMO, and organic. Each bottle contains 200 capsules, each with 750 milligrams of powerful organic cordyceps.

If you prefer powdered supplements, try the SoTru Medicinal Mushrooms Drink Mix. It includes six of the most powerful mushroom species, including reishi, turkey tail, maitake, and cordyceps. It's easy to harness their immune-supportive properties by simply mixing the powder into your favorite beverage.

The mushrooms used in this mix are fermented on organic oats, which provides additional gut health benefits, including prebiotic fibers. This powder supplement is certified organic, non-GMO, and gluten-free and comes in various flavors, including citrus and chocolate.

New Chapter's Reishi mushroom supplement capsule supports the immune system thanks to a variety of mushrooms, including organic reishi and shitake mushrooms. Reishi is a type of mushroom grown on hardwood in hot, humid climates such as China, Japan, and other Asian countries. It may help boost the immune system and fight cancer. When taken in supplement form, Shiitake mushrooms may have similar benefits to reishi mushrooms.

Each serving of two capsules provides 300 milligrams of Reishi and 120 milligrams each of Shiitake, Lion's Mane, Maitake, Poria, Turkey Tail, and Chaga mushrooms. New Chapter Immune Support capsules use technology to verify and guarantee each mushroom strain they use in their supplements, so you know exactly what you're taking. They’re also grown in the USA, organic, vegan, and non-GMO.

Reishi mushrooms are an important plant traditionally used in the medical systems of China, Japan, and Korea. They’ve also become one of the most popular, best selling supplemental mushrooms in the world—for good reason. Reishi mushrooms have plant compounds that may provide health benefits, including beta-glucan, a type of dietary soluble fiber. The purported health benefits of reishi mushrooms include increasing immune response, fighting inflammation, and improving blood glucose.

Host Defense's Longevity Support Reishi Capsules provide 550 milligrams of reishi per two-capsule serving. They're made with U.S. grown, organic mushroom mycelium, also known as the nutrient-rich part of the fungus.

Maitake mushrooms are edible and tasty, as they’ve been widely consumed in Asian diets for centuries. They contain functional nutrients similar to those found in Reishi mushrooms, including the prebiotic dietary fiber beta-glucan. There is still limited research in humans regarding the benefits of maitake mushroom supplements; however, some findings show these supplements may improve immune function.

Om Mushrooms verifies their supplements using third-party testing. They also grow, dry, and mill their own mushrooms in the USA. The product is certified organic, non-GMO, vegan, and gluten-free. Each 2-gram serving mixes easily into your favorite coffee, tea, or smoothie.

Wellmade Organic Superfood Mushroom powder

Chaga mushrooms are known for their antioxidants and grow primarily on birch bark in cold climates, including Russia, Northern Europe, Canada, and Alaska.

Thrive Market's Wellmade Organic Superfood Chaga supplement powder is certified organic, non-GMO, ethically sourced, and vegan. Each teaspoon serving contains 2 grams of certified organic Chaga cultured on organic whole oats. The nutrition-packed powder is easy to mix into your favorite coffee, matcha, or smoothie recipe.

Good to Know

It’s important to note mushroom supplements may interact with certain pharmaceuticals. It's important to check with your doctor before adding a mushroom supplement to your routine.

Cordyceps are a fungus that grows on the larvae of insects. For centuries, traditional healers have long been using them to purportedly increase energy, sex drive, and improve kidney function.

Moon Juice Cordyceps is a powder with a mildly sweet flavor that mixes well with coffee, tea, and plant-based milks, and can even be used in baking. It’s organically grown and harvested by hand. Celebrated for its powerful adaptogenic potential, this plant-based powder is anecdotally used by athletes to increase stamina and reduce fatigue. One teaspoon provides one gram of Organic Cordyceps extract.

Lion’s Mane mushrooms are white, shaggy, large mushrooms that actually resemble a lion’s mane when growing.

Pure Essence Lion’s Mane 4x is ultra-concentrated, non-GMO, and free of gluten and dairy. Each capsule provides 250 milligrams of Organic Lion's Mane Mushroom Extract (1:1) and 250 milligrams of Organic Lion's Mane Mushroom Extract (8:1) for a super concentrated product. Lion's Mane is also an excellent source of Beta-D glucans, which can support the immune system.

Final Verdict

For a mushroom supplement that tastes great, is made from high-quality organic ingredients, and is easy to mix into your favorite beverage, try Four Sigmatic's Mushroom Blend powder.

What Experts Say

“Mushroom supplements may be a strong source of B-vitamins and Vitamin C and therefore may promote a strong immune system. B-vitamins are important for brain function, infection prevention, and cell metabolism” -Nicole Bodin, MS, RD

Why Trust Verywell Fit?

As a Registered Dietitian, Alex Aldeborgh takes supplement recommendations seriously. She researches each product and vets it against clinical research, product reviews, and third-party testing sites. She would feel comfortable recommending the products chosen to her clients, as well as comfortable taking them herself.

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Article Sources

Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Martel J, Ojcius DM, Chang CJ, et al. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nat Rev Endocrinol. 2017;13(3):149-160. doi:10.1038/nrendo.2016.142
Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evid Based Complement Alternat Med. 2012;2012:1-8. doi:10.1155/2012/809614
Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27. doi:10.1142/S0192415X11008610
Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Ganoderma lucidum (Lingzhi or reishi): a medicinal mushroom. In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011.
Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014;2(2):14. doi:10.3978/j.issn.2305-5839.2014.01.05
Lam CS, Cheng LP, Zhou LM, Cheung YT, Zuo Z. Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review. Chin Med. 2020;15:75. Published 2020 Jul 25. doi:10.1186/s13020-020-00356-4
Panda A, Swain K. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. J Ayurveda Integr Med. 2011;2(1):9. doi:10.4103/0975-9476.78183

The 9 Best Mushroom Supplements of 2021, According to a Dietitian

And whether to choose a powder or capsule

Best Overall: Four Sigmatic Mushroom Blend

Best Budget: NOW Cordyceps 750mg

Best Powder: SoTru Medicinal Mushrooms Drink Mix

Best Capsule: New Chapter Reishi Mushroom LifeShield Immune Support

Best Reishi: Host Defense Reishi Capsules

Best Maitake: Om Mushroom Superfood Maitake Powder

Best Chaga: Wellmade Organic Superfood Mushroom Powder Chaga

Good to Know

Best Cordyceps: Moon Juice Cordyceps

Best Lion’s Mane: Pure Essence MyPure Lions Mane 4X