Artificial Sweeteners and Weight Loss

Can they actually cause weight gain?

Artificial sweeteners on a table.

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If you're trying to lose weight, you're probably searching for the best ways to cut calories from your diet. Using no-calorie sweeteners instead of sugar may help you create a calorie deficit

But should you use artificial sweeteners for weight loss? Some people worry that artificial sweeteners cause weight gain, not weight loss. And many healthy eaters are concerned about artificial sweetener safety.

Artificial Sweeteners

There are many artificial sweeteners to choose from. Some provide no calories while others provide a very small amount that is not likely to make a difference in your total daily calorie intake. Here's an overview of the most popular brands of artificial sweeteners.

  • Advantame: 20,000 times sweeter than sugar
  • Nutrasweet, Equal or Sugar Twin (Aspartame): 200 times sweeter than sugar
  • Splenda (Sucralose): 600 times sweeter than sugar
  • Sweet and Low, Sweet Twin, Sweet'N Low, Necta Sweet (Saccharin): 200-700 times sweeter than sugar
  • Sweet One, Sunett (Acesulfame Potassium or Ace-K): 200 times sweeter than sugar
  • Truvia, PureVia, Enliten (Stevia variations): 200-400 times sweeter than sugar

The U.S. Food and Drug Administration (FDA) provides more information about each sweetener permitted for use in the foods and drinks that you consume.


Many consumers are concerned about side effects of artificial sweeteners. But the issue of sweetener safety is highly controversial. So if you want to know if artificial sweeteners are safe, the answer will probably depend on who you ask.

Safe Sweeteners

Some high-intensity sweeteners are considered safe for consumption by the general public, according to the FDA. These include:

  • Acesulfame potassium (Ace-K)
  • Advantame
  • Aspartame
  • Neotame
  • Saccharin
  • Sucralose

The FDA also considers highly-purified steviol glycoside (Stevia) to be generally recognized as safe (GRAS).

So which sweeteners might be unsafe? In the United States, the FDA prohibits the use of cyclamate even though the sweetener is used in other countries. Whole-leaf and crude Stevia extracts also are not permitted for use as sweeteners.

If you have a condition called phenylketonuria (PKU), your body may not react well to aspartame. For this reason, the FDA says you should avoid or limit foods and drinks that contain aspartame.

But even though the FDA has determined certain products are safe for you to use, many health experts are still unconvinced. Some users even say that they experience side effects with artificial sweeteners.

Bruce Y. Lee, MD, associate professor of international health and director of the Global Obesity Prevention Center at Johns Hopkins University in Baltimore, MD, is one of those experts. According to Dr. Lee, consumers should be concerned about sweetener safety even if they are generally recognized as safe.

"I would recommend being cautious about artificial sweeteners. Newly introduced sweeteners haven’t been around long enough for long-term studies on health risk," Dr. Lee says.

Other experts express greater concern. Larry Goldfarb, DC, founder of Medical and Wellness Center of New Jersey, claims that there were political and financial motivations behind the approval of certain sweeteners.

"The public has been duped that artificial sweeteners are fine to use and no harmful effects have been shown to exist. Research has shown just the opposite," says Dr. Goldfarb.

Dr. Goldfarb also notes that some studies have shown a relationship between aspartame and several serious diseases including cancer. But the FDA stands by their safety rating, stating "aspartame is one of the most exhaustively studied substances in the human food supply, with more than 100 studies supporting its safety."

Weight Gain

Even if you're not concerned about the safety of the sweeteners, you may not want to use them for weight loss. Some experts believe that using artificial sweeteners may cause weight gain, not weight loss.

For years, researchers have been studying the way that our bodies and our brains react to low-calorie or no-calorie sweeteners.

Some studies have found that when we consume these sweeteners, we end up eating more food and consuming more calories overall.

Some scientists believe that because artificial sweeteners are so much sweeter than sugar, they train our brains to crave increasingly sweet foods. In addition, because these sweeteners do not provide calories, they confuse normal brain signals that tell us to stop eating when we've had enough food.

Other scientists think that eating artificially sweetened treats gives us an excuse to eat more food overall. For example, if you buy diet cookies, you might be tempted to eat more of them because you might think that they do less harm to your weight loss program. As a result, you may consume more calories overall.

But not all research studies have shown negative effects from artificial sweeteners. Some researchers have found that replacing high-calorie foods and beverages with lower calorie or no-calorie sweetened treats can lead to weight loss. One researcher said that the results are most dramatic when switching from high-calorie sodas to diet sodas with no calories.

So where does this leave you? Scientists say that trying to study eating behavior is too complicated to give exact answers. Even if a study says that artificial sweeteners may work for weight loss, your experience may be different.

To find the best plan for your health and well-being, you may want to think about how you use artificial sweeteners in your diet.

Weight Loss

If you currently eat a lot of foods with sugar, swapping them for foods with artificial sweeteners may be a reasonable first step. This process may help you become more thoughtful about your food choices and more careful about your meal planning.

"Ideally, it is best to cut down on all sweeteners as much as possible. But not everyone can do that," says Lee. "So, if there aren’t other options, then you could consider temporarily moving to artificial sweeteners from sugar. But again, ultimately, it is better to eventually move to natural means and reduce sweeteners in general."

Becoming mindful of your cravings and food choices might help you to reduce your dependence on sweeteners.

For example, you might crave a sweet soda or coffee drink in the afternoon to boost your energy levels. But even if you grab a diet drink with no calories, you may do more harm than good.

A caffeinated beverage dehydrates your body, which can cause fatigue. Drinking water instead boosts hydration, may improve your energy level, and provides zero calories.

Cutting Back

Dr. Lee notes that a sweet tooth is a learned phenomenon. "Like any habit, you can re-train yourself," he says. And Dr. Goldfarb agrees that the best first step is to re-program your taste buds. He offers a few tips to help reduce your dependence on sweets.

Eat Half and Eat Slowly

You will feel full if you eat slowly and then resist the temptation to finish the plate of food just because it's there. Eating more slowly helps your belly and your brain respond to the food that you've consumed. "Mindful eating" is one of the best ways to cut back on sugar and portion sizes in general.

Make Healthy Choices

Include healthy fats in your diet as they can help curb your appetite for sugar. Add avocado to your sandwich or salads or eat a single serving of salmon or tuna for dinner to feel more satisfied.

Give Yourself a Deadline

Reduce your sugar intake over a two week period and then just stop. You'll be surprised how easy it is. Cutting back on sugar will also give you room in your calorie budget to enjoy more nutritious diet-friendly foods.

Get Help

Reach out to experts if you can't cut sugar on your own. Seeking the care of a dietitian or nutritionist may be a good place to start. 

A Word From Verywell

Artificial sweeteners may help some people lose weight. But many experts remain concerned about side effects and weight gain. So choose naturally sweet foods like whole fruit to satisfy your sweet tooth and take advantage of the vitamins, minerals, and other benefits that whole foods provide. And reach out to your healthcare team if you are concerned about side effects of artificial sweeteners or need help cutting back.


4 Sources
Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. U.S. Food & Drug Administration. Additional information about high-intensity sweeteners permitted for use in food in the United States.

  2. US Food and Drug Administration. High-intensity sweeteners.

  3. Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep. 2017;19(12):64. doi:10.1007/s11894-017-0602-9

  4. Yang Q. Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010Yale J Biol Med. 2010;83(2):101–108.

Additional Reading

By Malia Frey, M.A., ACE-CHC, CPT
 Malia Frey is a weight loss expert, certified health coach, weight management specialist, personal trainer​, and fitness nutrition specialist.